Pervasive promoter hypermethylation of silenced TERT alleles in human cancers

BACKGROUND: In cancers, maintenance of telomeres often occurs through activation of the catalytic subunit of telomerase, encoded by TERT. Yet, most cancers show only modest levels of TERT gene expression, even in the context of activating hotspot promoter mutations (C228T and C250T). The role of epi...

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Bibliografski detalji
Izdano u:Cell Oncol (Dordr)
Glavni autori: Esopi, David, Graham, Mindy Kim, Brosnan-Cashman, Jacqueline A., Meyers, Jennifer, Vaghasia, Ajay, Gupta, Anuj, Kumar, Balasubramanian, Haffner, Michael C., Heaphy, Christopher M., De Marzo, Angelo M., Meeker, Alan K., Nelson, William G., Wheelan, Sarah J., Yegnasubramanian, Srinivasan
Format: Artigo
Jezik:Inglês
Izdano: Springer Netherlands 2020
Teme:
Original Paper
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7581602/
https://ncbi.nlm.nih.gov/pubmed/32468444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13402-020-00531-7
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