Pervasive promoter hypermethylation of silenced TERT alleles in human cancers

BACKGROUND: In cancers, maintenance of telomeres often occurs through activation of the catalytic subunit of telomerase, encoded by TERT. Yet, most cancers show only modest levels of TERT gene expression, even in the context of activating hotspot promoter mutations (C228T and C250T). The role of epi...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Cell Oncol (Dordr)
Hauptverfasser: Esopi, David, Graham, Mindy Kim, Brosnan-Cashman, Jacqueline A., Meyers, Jennifer, Vaghasia, Ajay, Gupta, Anuj, Kumar, Balasubramanian, Haffner, Michael C., Heaphy, Christopher M., De Marzo, Angelo M., Meeker, Alan K., Nelson, William G., Wheelan, Sarah J., Yegnasubramanian, Srinivasan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer Netherlands 2020
Schlagworte:
Original Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7581602/
https://ncbi.nlm.nih.gov/pubmed/32468444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13402-020-00531-7
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge