MYC drives overexpression of telomerase RNA (hTR/TERC) in prostate cancer

Telomerase consists of at least two essential elements, an RNA component hTR or TERC that contains the template for telomere DNA addition and a catalytic reverse transcriptase (TERT). While expression of TERT has been considered the key rate-limiting component for telomerase activity, increasing evi...

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Publicat a:J Pathol
Autors principals: Valle, Javier A Baena-Del, Zheng, Qizhi, Esopi, David M, Rubenstein, Michael, Hubbard, Gretchen K, Moncaliano, Maria C, Hruszkewycz, Andrew, Vaghasia, Ajay, Yegnasubramanian, Srinivasan, Wheelan, Sarah J, Meeker, Alan K, Heaphy, Christopher M, Graham, Mindy K, De Marzo, Angelo M
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5801764/
https://ncbi.nlm.nih.gov/pubmed/28888037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/path.4980
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