Functional loss of ATRX and TERC activates Alternative Lengthening of Telomeres (ALT) in LAPC4 prostate cancer cells

A key hallmark of cancer, unlimited replication, requires cancer cells to evade both replicative senescence and potentially lethal chromosomal instability induced by telomere dysfunction. The majority of cancers overcome these critical barriers by up-regulating telomerase, a telomere-specific revers...

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Publié dans:Mol Cancer Res
Auteurs principaux: Graham, Mindy K., Kim, Jiyoung, Da, Joseph, Brosnan-Cashman, Jacqueline A., Rizzo, Anthony, Del Valle, Javier A. Baena, Chia, Lionel, Rubenstein, Michael, Davis, Christine, Zheng, Qizhi, Cope, Leslie, Considine, Michael, Haffner, Michael C., De Marzo, Angelo M., Meeker, Alan K., Heaphy, Christopher M.
Format: Artigo
Langue:Inglês
Publié: 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6891209/
https://ncbi.nlm.nih.gov/pubmed/31611308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-19-0654
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