Functional loss of ATRX and TERC activates Alternative Lengthening of Telomeres (ALT) in LAPC4 prostate cancer cells

A key hallmark of cancer, unlimited replication, requires cancer cells to evade both replicative senescence and potentially lethal chromosomal instability induced by telomere dysfunction. The majority of cancers overcome these critical barriers by up-regulating telomerase, a telomere-specific revers...

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Bibliografski detalji
Izdano u:Mol Cancer Res
Glavni autori: Graham, Mindy K., Kim, Jiyoung, Da, Joseph, Brosnan-Cashman, Jacqueline A., Rizzo, Anthony, Del Valle, Javier A. Baena, Chia, Lionel, Rubenstein, Michael, Davis, Christine, Zheng, Qizhi, Cope, Leslie, Considine, Michael, Haffner, Michael C., De Marzo, Angelo M., Meeker, Alan K., Heaphy, Christopher M.
Format: Artigo
Jezik:Inglês
Izdano: 2019
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6891209/
https://ncbi.nlm.nih.gov/pubmed/31611308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-19-0654
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