Functional loss of ATRX and TERC activates Alternative Lengthening of Telomeres (ALT) in LAPC4 prostate cancer cells

A key hallmark of cancer, unlimited replication, requires cancer cells to evade both replicative senescence and potentially lethal chromosomal instability induced by telomere dysfunction. The majority of cancers overcome these critical barriers by up-regulating telomerase, a telomere-specific revers...

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Detalhes bibliográficos
Publicado no:Mol Cancer Res
Main Authors: Graham, Mindy K., Kim, Jiyoung, Da, Joseph, Brosnan-Cashman, Jacqueline A., Rizzo, Anthony, Del Valle, Javier A. Baena, Chia, Lionel, Rubenstein, Michael, Davis, Christine, Zheng, Qizhi, Cope, Leslie, Considine, Michael, Haffner, Michael C., De Marzo, Angelo M., Meeker, Alan K., Heaphy, Christopher M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6891209/
https://ncbi.nlm.nih.gov/pubmed/31611308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-19-0654
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