Functional loss of ATRX and TERC activates Alternative Lengthening of Telomeres (ALT) in LAPC4 prostate cancer cells

A key hallmark of cancer, unlimited replication, requires cancer cells to evade both replicative senescence and potentially lethal chromosomal instability induced by telomere dysfunction. The majority of cancers overcome these critical barriers by up-regulating telomerase, a telomere-specific revers...

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Veröffentlicht in:Mol Cancer Res
Hauptverfasser: Graham, Mindy K., Kim, Jiyoung, Da, Joseph, Brosnan-Cashman, Jacqueline A., Rizzo, Anthony, Del Valle, Javier A. Baena, Chia, Lionel, Rubenstein, Michael, Davis, Christine, Zheng, Qizhi, Cope, Leslie, Considine, Michael, Haffner, Michael C., De Marzo, Angelo M., Meeker, Alan K., Heaphy, Christopher M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6891209/
https://ncbi.nlm.nih.gov/pubmed/31611308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-19-0654
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