Functional loss of ATRX and TERC activates Alternative Lengthening of Telomeres (ALT) in LAPC4 prostate cancer cells

A key hallmark of cancer, unlimited replication, requires cancer cells to evade both replicative senescence and potentially lethal chromosomal instability induced by telomere dysfunction. The majority of cancers overcome these critical barriers by up-regulating telomerase, a telomere-specific revers...

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I publikationen:Mol Cancer Res
Huvudupphovsmän: Graham, Mindy K., Kim, Jiyoung, Da, Joseph, Brosnan-Cashman, Jacqueline A., Rizzo, Anthony, Del Valle, Javier A. Baena, Chia, Lionel, Rubenstein, Michael, Davis, Christine, Zheng, Qizhi, Cope, Leslie, Considine, Michael, Haffner, Michael C., De Marzo, Angelo M., Meeker, Alan K., Heaphy, Christopher M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2019
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6891209/
https://ncbi.nlm.nih.gov/pubmed/31611308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-19-0654
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