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Synthesis and structure–activity relationship studies of novel dihydropyridones as androgen receptor modulators
A library of 3-hydroxy-2,3-dihyrdropyridones was synthesized and their activity as antiandrogens was tested in the human prostate cancer cell lines LNCaP. Structure–activity relationship studies resulted in the identification of a potent compound, whose activity is comparable to MDV3100. Homology mo...
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| Publicado no: | J Med Chem |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7581280/ https://ncbi.nlm.nih.gov/pubmed/24044500 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm301714s |
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