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Electrophysiological characterization of the modified hERG(T) potassium channel used to obtain the first cryo‐EM hERG structure
The voltage‐gated hERG (human‐Ether‐à‐go‐go Related Gene) K(+) channel plays a fundamental role in cardiac action potential repolarization. Loss‐of‐function mutations or pharmacological inhibition of hERG leads to long QT syndrome, whilst gain‐of‐function mutations lead to short QT syndrome. A recen...
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| Pubblicato in: | Physiol Rep |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
John Wiley and Sons Inc.
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7580876/ https://ncbi.nlm.nih.gov/pubmed/33091232 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.14568 |
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