Metabolic plasticity of IDH1-mutant glioma cell lines is responsible for low sensitivity to glutaminase inhibition

BACKGROUND: Targeting glutamine metabolism in cancer has become an increasingly vibrant area of research. Mutant IDH1 (IDH1(mut)) gliomas are considered good candidates for targeting this pathway because of the contribution of glutamine to their newly acquired function: synthesis of 2-hydroxyglutara...

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Bibliografski detalji
Izdano u:Cancer Metab
Glavni autori: Ruiz-Rodado, Victor, Lita, Adrian, Dowdy, Tyrone, Celiku, Orieta, Saldana, Alejandra Cavazos, Wang, Herui, Yang, Chun Zhang, Chari, Raj, Li, Aiguo, Zhang, Wei, Song, Hua, Zhang, Meili, Ahn, Susie, Davis, Dionne, Chen, Xiang, Zhuang, Zhengping, Herold-Mende, Christel, Walters, Kylie J., Gilbert, Mark R., Larion, Mioara
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2020
Teme:
Research
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7579920/
https://ncbi.nlm.nih.gov/pubmed/33101674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40170-020-00229-2
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