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CBMT-44. METABOLIC PLASTICITY AND HETEROGENEITY IN IDH1(MUT) CELL LINES PRODUCES RESISTANCE TO GLUTAMINASE INHIBITION BY CB839
BACKGROUND: Mutant IDH1 (IDH1(mut)) gliomas have characteristic genetic and metabolic profiles and exhibit phenotype that is distinct from their wild-type counterparts. The glutamine/glutamate pathway has been hypothesized as a selective therapeutic target in IDH1(mut) gliomas. However, little infor...
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| Publicado no: | Neuro Oncol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6217218/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.163 |
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