CBMT-44. METABOLIC PLASTICITY AND HETEROGENEITY IN IDH1(MUT) CELL LINES PRODUCES RESISTANCE TO GLUTAMINASE INHIBITION BY CB839

BACKGROUND: Mutant IDH1 (IDH1(mut)) gliomas have characteristic genetic and metabolic profiles and exhibit phenotype that is distinct from their wild-type counterparts. The glutamine/glutamate pathway has been hypothesized as a selective therapeutic target in IDH1(mut) gliomas. However, little infor...

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Detaylı Bibliyografya
Yayımlandı:Neuro Oncol
Asıl Yazarlar: Ruiz Rodado, Victor, Lita, Adrian, Dowdy, Tyrone, Saldana, Alejandra Cavazos, Gilbert, Mark, Larion, Mioara
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2018
Konular:
Abstracts
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6217218/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.163
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