Metabolic plasticity of IDH1-mutant glioma cell lines is responsible for low sensitivity to glutaminase inhibition

BACKGROUND: Targeting glutamine metabolism in cancer has become an increasingly vibrant area of research. Mutant IDH1 (IDH1(mut)) gliomas are considered good candidates for targeting this pathway because of the contribution of glutamine to their newly acquired function: synthesis of 2-hydroxyglutara...

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Publicat a:Cancer Metab
Autors principals: Ruiz-Rodado, Victor, Lita, Adrian, Dowdy, Tyrone, Celiku, Orieta, Saldana, Alejandra Cavazos, Wang, Herui, Yang, Chun Zhang, Chari, Raj, Li, Aiguo, Zhang, Wei, Song, Hua, Zhang, Meili, Ahn, Susie, Davis, Dionne, Chen, Xiang, Zhuang, Zhengping, Herold-Mende, Christel, Walters, Kylie J., Gilbert, Mark R., Larion, Mioara
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2020
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7579920/
https://ncbi.nlm.nih.gov/pubmed/33101674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40170-020-00229-2
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