Metabolic plasticity of IDH1-mutant glioma cell lines is responsible for low sensitivity to glutaminase inhibition

BACKGROUND: Targeting glutamine metabolism in cancer has become an increasingly vibrant area of research. Mutant IDH1 (IDH1(mut)) gliomas are considered good candidates for targeting this pathway because of the contribution of glutamine to their newly acquired function: synthesis of 2-hydroxyglutara...

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Detalhes bibliográficos
Publicado no:Cancer Metab
Main Authors: Ruiz-Rodado, Victor, Lita, Adrian, Dowdy, Tyrone, Celiku, Orieta, Saldana, Alejandra Cavazos, Wang, Herui, Yang, Chun Zhang, Chari, Raj, Li, Aiguo, Zhang, Wei, Song, Hua, Zhang, Meili, Ahn, Susie, Davis, Dionne, Chen, Xiang, Zhuang, Zhengping, Herold-Mende, Christel, Walters, Kylie J., Gilbert, Mark R., Larion, Mioara
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
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Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7579920/
https://ncbi.nlm.nih.gov/pubmed/33101674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40170-020-00229-2
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