5-FU promotes stemness of colorectal cancer via p53-mediated WNT/β-catenin pathway activation

5-Fluorouracil (5-FU) remains the first-line treatment for colorectal cancer (CRC). Although 5-FU initially de-bulks the tumor mass, recurrence after chemotherapy is the barrier to effective clinical outcomes for CRC patients. Here, we demonstrate that p53 promotes WNT3 transcription, leading to act...

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Vydáno v:Nat Commun
Hlavní autoři: Cho, Yong-Hee, Ro, Eun Ji, Yoon, Jeong-Su, Mizutani, Tomohiro, Kang, Dong-Woo, Park, Jong-Chan, Il Kim, Tae, Clevers, Hans, Choi, Kang-Yell
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7578039/
https://ncbi.nlm.nih.gov/pubmed/33087710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19173-2
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