A Genome-wide Polygenic Score, Clinical Risk Factors, and Long-term Trajectories of Coronary Artery Disease

OBJECTIVES: To determine the relationship of a genome-wide polygenic score for coronary artery disease (GPS(CAD)) to lifetime trajectories of CAD risk, directly compare its predictive capacity to traditional risk factors, and assess its interplay with the Pooled Cohort Equations (PCE). APPROACH AND...

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Veröffentlicht in:Arterioscler Thromb Vasc Biol
Hauptverfasser: Hindy, George, Aragam, Krishna G., Ng, Kenney, Chaffin, Mark, Lotta, Luca A., Baras, Aris, Drake, Isabel, Orho-Melander, Marju, Melander, Olle, Kathiresan, Sekar, Khera, Amit V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7577949/
https://ncbi.nlm.nih.gov/pubmed/32957805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.120.314856
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