A Genome-wide Polygenic Score, Clinical Risk Factors, and Long-term Trajectories of Coronary Artery Disease

OBJECTIVES: To determine the relationship of a genome-wide polygenic score for coronary artery disease (GPS(CAD)) to lifetime trajectories of CAD risk, directly compare its predictive capacity to traditional risk factors, and assess its interplay with the Pooled Cohort Equations (PCE). APPROACH AND...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Arterioscler Thromb Vasc Biol
Prif Awduron: Hindy, George, Aragam, Krishna G., Ng, Kenney, Chaffin, Mark, Lotta, Luca A., Baras, Aris, Drake, Isabel, Orho-Melander, Marju, Melander, Olle, Kathiresan, Sekar, Khera, Amit V.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7577949/
https://ncbi.nlm.nih.gov/pubmed/32957805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.120.314856
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