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Polygenic Risk Score for Coronary Heart Disease Modifies the Elevated Risk by Cigarette Smoking for Disease Incidence

BACKGROUND: Coronary heart disease (CHD) is a multifactorial disease with both genetic and environmental components. Smoking is the most important modifiable risk factor for CHD. Our aim was to test whether the increased CHD incidence by smoking is modified by genetic predisposition to CHD. METHODS...

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Detalhes bibliográficos
Publicado no:Circ Genom Precis Med
Main Authors: Hindy, George, Wiberg, Frans, Almgren, Peter, Melander, Olle, Orho-Melander, Marju
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6319562/
https://ncbi.nlm.nih.gov/pubmed/29874179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCGEN.117.001856
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