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Polygenic Risk Score for Coronary Heart Disease Modifies the Elevated Risk by Cigarette Smoking for Disease Incidence

BACKGROUND: Coronary heart disease (CHD) is a multifactorial disease with both genetic and environmental components. Smoking is the most important modifiable risk factor for CHD. Our aim was to test whether the increased CHD incidence by smoking is modified by genetic predisposition to CHD. METHODS...

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Опубликовано в: :Circ Genom Precis Med
Главные авторы: Hindy, George, Wiberg, Frans, Almgren, Peter, Melander, Olle, Orho-Melander, Marju
Формат: Artigo
Язык:Inglês
Опубликовано: Lippincott Williams & Wilkins 2018
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6319562/
https://ncbi.nlm.nih.gov/pubmed/29874179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCGEN.117.001856
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