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Polygenic Risk Score for Coronary Heart Disease Modifies the Elevated Risk by Cigarette Smoking for Disease Incidence

BACKGROUND: Coronary heart disease (CHD) is a multifactorial disease with both genetic and environmental components. Smoking is the most important modifiable risk factor for CHD. Our aim was to test whether the increased CHD incidence by smoking is modified by genetic predisposition to CHD. METHODS...

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Détails bibliographiques
Publié dans:Circ Genom Precis Med
Auteurs principaux: Hindy, George, Wiberg, Frans, Almgren, Peter, Melander, Olle, Orho-Melander, Marju
Format: Artigo
Langue:Inglês
Publié: Lippincott Williams & Wilkins 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6319562/
https://ncbi.nlm.nih.gov/pubmed/29874179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCGEN.117.001856
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