A Genome-wide Polygenic Score, Clinical Risk Factors, and Long-term Trajectories of Coronary Artery Disease

OBJECTIVES: To determine the relationship of a genome-wide polygenic score for coronary artery disease (GPS(CAD)) to lifetime trajectories of CAD risk, directly compare its predictive capacity to traditional risk factors, and assess its interplay with the Pooled Cohort Equations (PCE). APPROACH AND...

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Pubblicato in:Arterioscler Thromb Vasc Biol
Autori principali: Hindy, George, Aragam, Krishna G., Ng, Kenney, Chaffin, Mark, Lotta, Luca A., Baras, Aris, Drake, Isabel, Orho-Melander, Marju, Melander, Olle, Kathiresan, Sekar, Khera, Amit V.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7577949/
https://ncbi.nlm.nih.gov/pubmed/32957805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.120.314856
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