Cardiometabolic Polygenic Risk Scores and Osteoarthritis Outcomes: A Mendelian Randomization Study Using Data From the Malmö Diet and Cancer Study and the UK Biobank

OBJECTIVE: To investigate the causal role of cardiometabolic risk factors in osteoarthritis (OA) using associated genetic variants. METHODS: We studied 27,691 adults from the Malmö Diet and Cancer Study (MDCS) and replicated novel findings among 376,435 adults from the UK Biobank. Trait‐specific pol...

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Detalhes bibliográficos
Publicado no:Arthritis Rheumatol
Main Authors: Hindy, George, Åkesson, Kristina E., Melander, Olle, Aragam, Krishna G., Haas, Mary E., Nilsson, Peter M., Kadam, Umesh T., Orho‐Melander, Marju
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Osteoarthritis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6563114/
https://ncbi.nlm.nih.gov/pubmed/30615301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.40812
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