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Polygenic Risk Score for Coronary Heart Disease Modifies the Elevated Risk by Cigarette Smoking for Disease Incidence

BACKGROUND: Coronary heart disease (CHD) is a multifactorial disease with both genetic and environmental components. Smoking is the most important modifiable risk factor for CHD. Our aim was to test whether the increased CHD incidence by smoking is modified by genetic predisposition to CHD. METHODS...

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Bibliografske podrobnosti
izdano v:Circ Genom Precis Med
Main Authors: Hindy, George, Wiberg, Frans, Almgren, Peter, Melander, Olle, Orho-Melander, Marju
Format: Artigo
Jezik:Inglês
Izdano: Lippincott Williams & Wilkins 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6319562/
https://ncbi.nlm.nih.gov/pubmed/29874179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCGEN.117.001856
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