Familial Alzheimer’s disease patient-derived neurons reveal distinct mutation-specific effects on amyloid beta

Familial Alzheimer’s disease (fAD) mutations alter amyloid precursor protein (APP) cleavage by γ-secretase, increasing the proportion of longer amyloidogenic amyloid-β (Aβ) peptides. Using five control induced pluripotent stem cell (iPSC) lines and seven iPSC lines generated from fAD patients, we in...

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Detaylı Bibliyografya
Yayımlandı:Mol Psychiatry
Asıl Yazarlar: Arber, Charles, Toombs, Jamie, Lovejoy, Christopher, Ryan, Natalie S., Paterson, Ross W., Willumsen, Nanet, Gkanatsiou, Eleni, Portelius, Erik, Blennow, Kaj, Heslegrave, Amanda, Schott, Jonathan M., Hardy, John, Lashley, Tammaryn, Fox, Nick C., Zetterberg, Henrik, Wray, Selina
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7577860/
https://ncbi.nlm.nih.gov/pubmed/30980041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41380-019-0410-8
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