Familial Alzheimer’s disease patient-derived neurons reveal distinct mutation-specific effects on amyloid beta

Familial Alzheimer’s disease (fAD) mutations alter amyloid precursor protein (APP) cleavage by γ-secretase, increasing the proportion of longer amyloidogenic amyloid-β (Aβ) peptides. Using five control induced pluripotent stem cell (iPSC) lines and seven iPSC lines generated from fAD patients, we in...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Mol Psychiatry
Auteurs principaux: Arber, Charles, Toombs, Jamie, Lovejoy, Christopher, Ryan, Natalie S., Paterson, Ross W., Willumsen, Nanet, Gkanatsiou, Eleni, Portelius, Erik, Blennow, Kaj, Heslegrave, Amanda, Schott, Jonathan M., Hardy, John, Lashley, Tammaryn, Fox, Nick C., Zetterberg, Henrik, Wray, Selina
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2019
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7577860/
https://ncbi.nlm.nih.gov/pubmed/30980041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41380-019-0410-8
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires