Amyloid precursor protein processing in human neurons with an allelic series of the PSEN1 intron 4 deletion mutation and total presenilin-1 knockout

Mutations in presenilin-1 (PSEN1), encoding the catalytic subunit of the amyloid precursor protein-processing enzyme γ-secretase, cause familial Alzheimer’s disease. However, the mechanism of disease is yet to be fully understood and it remains contentious whether mutations exert their effects predo...

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Bibliographische Detailangaben
Veröffentlicht in:Brain Commun
Hauptverfasser: Arber, Charles, Villegas-Llerena, Claudio, Toombs, Jamie, Pocock, Jennifer M, Ryan, Natalie S, Fox, Nick C, Zetterberg, Henrik, Hardy, John, Wray, Selina
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2019
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7212081/
https://ncbi.nlm.nih.gov/pubmed/32395715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/braincomms/fcz024
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