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Novel presenilin 1 and 2 double Knock-out cell line for in vitro validation of PSEN1 and PSEN2 mutations
Mutations in APP (amyloid precursor protein), PSEN1 (presenilin 1) or PSEN2 (presenilin 2) are the main cause of early-onset familial forms of Alzheimer’s disease (autosomal dominant AD or ADAD). These genes affect γ-secretase-dependent generation of Amyloid β (Aβ) peptides, the main constituent of...
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| Publicado no: | Neurobiol Dis |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7515654/ https://ncbi.nlm.nih.gov/pubmed/32032730 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2020.104785 |
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