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Novel presenilin 1 and 2 double Knock-out cell line for in vitro validation of PSEN1 and PSEN2 mutations
Mutations in APP (amyloid precursor protein), PSEN1 (presenilin 1) or PSEN2 (presenilin 2) are the main cause of early-onset familial forms of Alzheimer’s disease (autosomal dominant AD or ADAD). These genes affect γ-secretase-dependent generation of Amyloid β (Aβ) peptides, the main constituent of...
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| 出版年: | Neurobiol Dis |
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| 主要な著者: | , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7515654/ https://ncbi.nlm.nih.gov/pubmed/32032730 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2020.104785 |
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