Familial Alzheimer’s disease patient-derived neurons reveal distinct mutation-specific effects on amyloid beta

Familial Alzheimer’s disease (fAD) mutations alter amyloid precursor protein (APP) cleavage by γ-secretase, increasing the proportion of longer amyloidogenic amyloid-β (Aβ) peptides. Using five control induced pluripotent stem cell (iPSC) lines and seven iPSC lines generated from fAD patients, we in...

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發表在:Mol Psychiatry
Main Authors: Arber, Charles, Toombs, Jamie, Lovejoy, Christopher, Ryan, Natalie S., Paterson, Ross W., Willumsen, Nanet, Gkanatsiou, Eleni, Portelius, Erik, Blennow, Kaj, Heslegrave, Amanda, Schott, Jonathan M., Hardy, John, Lashley, Tammaryn, Fox, Nick C., Zetterberg, Henrik, Wray, Selina
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2019
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7577860/
https://ncbi.nlm.nih.gov/pubmed/30980041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41380-019-0410-8
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