Light-regulated allosteric switch enables temporal and subcellular control of enzyme activity

Engineered allosteric regulation of protein activity provides significant advantages for the development of robust and broadly applicable tools. However, the application of allosteric switches in optogenetics has been scarce and suffers from critical limitations. Here, we report an optogenetic appro...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:eLife
Prif Awduron: Shaaya, Mark, Fauser, Jordan, Zhurikhina, Anastasia, Conage-Pough, Jason E, Huyot, Vincent, Brennan, Martin, Flower, Cameron T, Matsche, Jacob, Khan, Shahzeb, Natarajan, Viswanathan, Rehman, Jalees, Kota, Pradeep, White, Forest M, Tsygankov, Denis, Karginov, Andrei V
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: eLife Sciences Publications, Ltd 2020
Pynciau:
Biochemistry and Chemical Biology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7577742/
https://ncbi.nlm.nih.gov/pubmed/32965214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.60647
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