Lanean...

Covalent Inhibitors of Protein-Protein Interactions Targeting Lysine, Tyrosine, or Histidine Residues

We have recently reported on a series of Lys-covalent agents targeting the BIR3 domain of the X-linked Inhibitor of Apoptosis Protein (XIAP) using a benzamide-sulfonyl fluoride warhead. Using XIAP as a model system, we further investigated a variety of additional warheads that can be easily incorpor...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Med Chem
Egile Nagusiak: Gambini, Luca, Baggio, Carlo, Udompholkul, Parima, Jossart, Jennifer, Salem, Ahmed F., Perry, J. Jefferson P., Pellecchia, Maurizio
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2019
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7577563/
https://ncbi.nlm.nih.gov/pubmed/31095386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b00561
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!