Antibodies exhibit multiple paratope states influencing V(H)–V(L) domain orientations

In the last decades, antibodies have emerged as one of the most important and successful classes of biopharmaceuticals. The highest variability and diversity of an antibody is concentrated on six hypervariable loops, also known as complementarity determining regions (CDRs) shaping the antigen-bindin...

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Publicado en:Commun Biol
Autores principales: Fernández-Quintero, Monica L., Pomarici, Nancy D., Math, Barbara A., Kroell, Katharina B., Waibl, Franz, Bujotzek, Alexander, Georges, Guy, Liedl, Klaus R.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7576833/
https://ncbi.nlm.nih.gov/pubmed/33082531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-020-01319-z
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