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Antibodies exhibit multiple paratope states influencing V(H)–V(L) domain orientations
In the last decades, antibodies have emerged as one of the most important and successful classes of biopharmaceuticals. The highest variability and diversity of an antibody is concentrated on six hypervariable loops, also known as complementarity determining regions (CDRs) shaping the antigen-bindin...
Enregistré dans:
| Publié dans: | Commun Biol |
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| Auteurs principaux: | , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group UK
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7576833/ https://ncbi.nlm.nih.gov/pubmed/33082531 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-020-01319-z |
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