Antibodies exhibit multiple paratope states influencing V(H)–V(L) domain orientations

In the last decades, antibodies have emerged as one of the most important and successful classes of biopharmaceuticals. The highest variability and diversity of an antibody is concentrated on six hypervariable loops, also known as complementarity determining regions (CDRs) shaping the antigen-bindin...

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Vydáno v:Commun Biol
Hlavní autoři: Fernández-Quintero, Monica L., Pomarici, Nancy D., Math, Barbara A., Kroell, Katharina B., Waibl, Franz, Bujotzek, Alexander, Georges, Guy, Liedl, Klaus R.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7576833/
https://ncbi.nlm.nih.gov/pubmed/33082531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-020-01319-z
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