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Antibodies exhibit multiple paratope states influencing V(H)–V(L) domain orientations

In the last decades, antibodies have emerged as one of the most important and successful classes of biopharmaceuticals. The highest variability and diversity of an antibody is concentrated on six hypervariable loops, also known as complementarity determining regions (CDRs) shaping the antigen-bindin...

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Detalhes bibliográficos
Publicado no:Commun Biol
Main Authors: Fernández-Quintero, Monica L., Pomarici, Nancy D., Math, Barbara A., Kroell, Katharina B., Waibl, Franz, Bujotzek, Alexander, Georges, Guy, Liedl, Klaus R.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7576833/
https://ncbi.nlm.nih.gov/pubmed/33082531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-020-01319-z
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