The Oncometabolite 5′-Deoxy-5′-Methylthioadenosine Blocks Multiple Signaling Pathways of NK Cell Activation

Tumor cells develop various mechanisms to escape immune surveillance. In this context, oncometabolites secreted by tumor cells due to deregulated metabolic pathways, have been in the spotlight of researchers during the last years. 5′-Deoxy-5′-methylthioadenosine (MTA) phosphorylase (MTAP) deficiency...

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Bibliographic Details
Published in:Front Immunol
Main Authors: Jacobs, Benedikt, Schlögl, Sebastian, Strobl, Carolin Dorothea, Völkl, Simon, Stoll, Andrej, Mougiakakos, Dimitrios, Malmberg, Karl-Johan, Mackensen, Andreas, Aigner, Michael
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7573074/
https://ncbi.nlm.nih.gov/pubmed/33123121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.02128
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