The Oncometabolite 5′-Deoxy-5′-Methylthioadenosine Blocks Multiple Signaling Pathways of NK Cell Activation

Tumor cells develop various mechanisms to escape immune surveillance. In this context, oncometabolites secreted by tumor cells due to deregulated metabolic pathways, have been in the spotlight of researchers during the last years. 5′-Deoxy-5′-methylthioadenosine (MTA) phosphorylase (MTAP) deficiency...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Jacobs, Benedikt, Schlögl, Sebastian, Strobl, Carolin Dorothea, Völkl, Simon, Stoll, Andrej, Mougiakakos, Dimitrios, Malmberg, Karl-Johan, Mackensen, Andreas, Aigner, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7573074/
https://ncbi.nlm.nih.gov/pubmed/33123121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.02128
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