Suppressive effects of tumor cell-derived 5′-deoxy-5′-methylthioadenosine on human T cells

The immunosuppressive tumor microenvironment represents one of the main obstacles for immunotherapy of cancer. The tumor milieu is among others shaped by tumor metabolites such as 5′-deoxy-5′-methylthioadenosine (MTA). Increased intratumoral MTA levels result from a lack of the MTA-catabolizing enzy...

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Bibliographic Details
Published in:Oncoimmunology
Main Authors: Henrich, Frederik C., Singer, Katrin, Poller, Kerstin, Bernhardt, Luise, Strobl, Carolin D., Limm, Katharina, Ritter, Axel P., Gottfried, Eva, Völkl, Simon, Jacobs, Benedikt, Peter, Katrin, Mougiakakos, Dimitrios, Dettmer, Katja, Oefner, Peter J., Bosserhoff, Anja-Katrin, Kreutz, Marina P., Aigner, Michael, Mackensen, Andreas
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2016
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5007975/
https://ncbi.nlm.nih.gov/pubmed/27622058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2016.1184802
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