Suppressive effects of tumor cell-derived 5′-deoxy-5′-methylthioadenosine on human T cells

The immunosuppressive tumor microenvironment represents one of the main obstacles for immunotherapy of cancer. The tumor milieu is among others shaped by tumor metabolites such as 5′-deoxy-5′-methylthioadenosine (MTA). Increased intratumoral MTA levels result from a lack of the MTA-catabolizing enzy...

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Detalhes bibliográficos
Publicado no:Oncoimmunology
Main Authors: Henrich, Frederik C., Singer, Katrin, Poller, Kerstin, Bernhardt, Luise, Strobl, Carolin D., Limm, Katharina, Ritter, Axel P., Gottfried, Eva, Völkl, Simon, Jacobs, Benedikt, Peter, Katrin, Mougiakakos, Dimitrios, Dettmer, Katja, Oefner, Peter J., Bosserhoff, Anja-Katrin, Kreutz, Marina P., Aigner, Michael, Mackensen, Andreas
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2016
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5007975/
https://ncbi.nlm.nih.gov/pubmed/27622058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2016.1184802
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