Down-Regulation of Methylthioadenosine Phosphorylase (MTAP) Induces Progression of Hepatocellular Carcinoma via Accumulation of 5′-Deoxy-5′-Methylthioadenosine (MTA)

Recently, we have shown that down-regulation of methylthioadenosine phosphorylase (MTAP) in hepatocellular carcinoma (HCC) cells enhances the invasive potential and the resistance against cytokines. Here, we aimed at investigating the molecular mechanism underlying this tumor-promoting effect and ex...

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Detalhes bibliográficos
Main Authors: Kirovski, Georgi, Stevens, Axel P., Czech, Barbara, Dettmer, Katja, Weiss, Thomas S., Wild, Peter, Hartmann, Arndt, Bosserhoff, Anja K., Oefner, Peter J., Hellerbrand, Claus
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2011
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069916/
https://ncbi.nlm.nih.gov/pubmed/21356366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2010.11.059
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