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Targeting tumors that lack methylthioadenosine phosphorylase (MTAP) activity: Current strategies
Many solid tumors and hematologic malignancies lack expression of the enzyme methylthioadenosine phosphorylase (MTAP), due either to deletion of the MTAP gene or to methylation of the MTAP promoter. In cells that have MTAP, its natural substrate, methylthioadenosine (MTA), generated during polyamine...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Landes Bioscience
2011
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3084968/ https://ncbi.nlm.nih.gov/pubmed/21301207 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.11.7.14948 |
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