Methylthioadenosine phosphorylase (MTAP)-deficient T-cell ALL xenografts are sensitive to pralatrexate and 6-thioguanine alone and in combination

PURPOSE: To investigate the effectiveness of a combination of 6-thioguanine (6-TG) and pralatrexate (PDX) in methylthioadenosine phosphorylase (MTAP)-deficient T-cell acute lymphoblastic leukemia (T-cell ALL). METHODS: CCRF-CEM (MTAP(−/−)) and Molt4 (MTAP(+/+)) T-cell ALL cell lines were treated wit...

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Detalhes bibliográficos
Publicado no:Cancer Chemother Pharmacol
Main Authors: Tedeschi, Philip M., Kathari, Yamini K., Johnson-Farley, Nadine, Bertino, Joseph R.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2015
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4441744/
https://ncbi.nlm.nih.gov/pubmed/25917288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-015-2747-2
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