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Chemical Genetic Screening for Compounds that Preferentially Inhibit Growth of Methylthioadenosine Phosphorylase (MTAP) Deficient Saccharomyces Cerevisiae

Methylthioadenosine phosphorylase (MTAP), a key enzyme in the methionine salvage pathway, is inactivated in a variety of human cancers. Since all human tissues express MTAP, it would be of potential interest to identify compounds that selectively inhibit the growth of MTAP deficient cells. To determ...

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Detaylı Bibliyografya
Asıl Yazarlar: Kadariya, Yuwaraj, Tang, Baiqing, Myers, Cynthia B., Fukui, Jami, Peterson, Jeffrey R., Kruger, Warren D.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2010
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3019245/
https://ncbi.nlm.nih.gov/pubmed/21131597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1087057110386371
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