Mice Heterozygous for Germline Mutations in Methylthioadenosine Phosphorylase (MTAP) Die Prematurely of T-cell Lymphoma

Large homozygous deletions of 9p21 that inactivate CDKN2A, ARF, and MTAP are common in a wide variety of human cancers. The role for CDKN2A and ARF in tumorigenesis is well established, but whether MTAP loss directly affects tumorigenesis is unclear. MTAP encodes the enzyme methylthioadenosine phosp...

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Bibliographic Details
Main Authors:	Kadariya, Yuwaraj, Yin, Bu, Tang, Baiqing, Shinton, Susan A., Quinlivan, Eoin P., Hua, Xiang, Klein-Szanto, Andres, Al-Saleem, Tahseen I., Bassing, Craig H., Hardy, Richard R., Kruger, Warren D.
Format:	Artigo
Language:	Inglês
Published:	2009
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2757012/ https://ncbi.nlm.nih.gov/pubmed/19567676 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-0145
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Mice Heterozygous for Germline Mutations in Methylthioadenosine Phosphorylase (MTAP) Die Prematurely of T-cell Lymphoma

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