Germline Mutations in Mtap Cooperate with Myc to Accelerate Tumorigenesis in Mice

OBJECTIVE: The gene encoding the methionine salvage pathway methylthioadenosine phosphorylase (MTAP) is a tumor suppressor gene that is frequently inactivated in a wide variety of human cancers. In this study, we have examined if heterozygosity for a null mutation in Mtap (Mtap(lacZ)) could accelera...

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Hlavní autoři: Kadariya, Yuwaraj, Tang, Baiqing, Wang, Liqun, Al-Saleem, Tahseen, Hayakawa, Kyoko, Slifker, Michael J., Kruger, Warren D.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2013
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3694069/
https://ncbi.nlm.nih.gov/pubmed/23840755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0067635
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