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Germline Mutations in Mtap Cooperate with Myc to Accelerate Tumorigenesis in Mice
OBJECTIVE: The gene encoding the methionine salvage pathway methylthioadenosine phosphorylase (MTAP) is a tumor suppressor gene that is frequently inactivated in a wide variety of human cancers. In this study, we have examined if heterozygosity for a null mutation in Mtap (Mtap(lacZ)) could accelera...
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| Asıl Yazarlar: | , , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Public Library of Science
2013
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3694069/ https://ncbi.nlm.nih.gov/pubmed/23840755 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0067635 |
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