Leucovorin rescue allows effective high-dose pralatrexate treatment and an increase in therapeutic index in mesothelioma xenografts

PURPOSE: To investigate the ability of leucovorin (LV) to abrogate dose-limiting toxicities of pralatrexate (PDX) while maintaining efficacy, in vivo. METHODS: H2052 mesothelioma cells were treated with the antifolates methotrexate (MTX), PDX and pemetrexed, with and without LV rescue 24 h later. Ce...

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Autors principals: Tedeschi, Philip M., Kathari, Yamini K., Farooqi, Iqra N., Bertino, Joseph R.
Format: Artigo
Idioma:Inglês
Publicat: Springer Berlin Heidelberg 2014
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4209237/
https://ncbi.nlm.nih.gov/pubmed/25205429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-014-2580-z
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