Overexpression of the Mitochondrial Folate and Glycine–Serine Pathway: A New Determinant of Methotrexate Selectivity in Tumors

بواسطة Vazquez, Alexei, Tedeschi, Philip M., Bertino, Joseph R.
منشور في 2012

Mitochondrial Methylene Tetrahydrofolate Dehydrogenase (MTHFD2) Overexpression is Associated with Tumor Cell Proliferation and is a Novel Target for Drug Development

بواسطة Tedeschi, Philip M., Vazquez, Alexei, Kerrigan, John E., Bertino, Joseph R.
الحاوية / القاعدة Mol Cancer Res (2015)

MTHFD2- a new twist?

بواسطة Tedeschi, Philip M., Scotto, Kathleen W., Kerrigan, John, Bertino, Joseph R.
الحاوية / القاعدة Oncotarget (2016)

Leucovorin rescue allows effective high-dose pralatrexate treatment and an increase in therapeutic index in mesothelioma xenografts

بواسطة Tedeschi, Philip M., Kathari, Yamini K., Farooqi, Iqra N., Bertino, Joseph R.
منشور في 2014

Methylthioadenosine phosphorylase (MTAP)-deficient T-cell ALL xenografts are sensitive to pralatrexate and 6-thioguanine alone and in combination

بواسطة Tedeschi, Philip M., Kathari, Yamini K., Johnson-Farley, Nadine, Bertino, Joseph R.
الحاوية / القاعدة Cancer Chemother Pharmacol (2015)

Suppression of Cytosolic NADPH Pool by Thionicotinamide Increases Oxidative Stress and Synergizes with Chemotherapy

بواسطة Tedeschi, Philip M., Lin, HongXia, Gounder, Murugesan, Kerrigan, John E., Abali, Emine Ercikan, Scotto, Kathleen, Bertino, Joseph R.
الحاوية / القاعدة Mol Pharmacol (2015)

The metabolic demands of cancer cells are coupled to their size and protein synthesis rates

بواسطة Dolfi, Sonia C, Chan, Leo Li-Ying, Qiu, Jean, Tedeschi, Philip M, Bertino, Joseph R, Hirshfield, Kim M, Oltvai, Zoltán N, Vazquez, Alexei
منشور في 2013

Quantification of folate metabolism using transient metabolic flux analysis

بواسطة Tedeschi, Philip M, Johnson-Farley, Nadine, Lin, Hongxia, Shelton, Laura M, Ooga, Takushi, Mackay, Gillian, Van Den Broek, Niels, Bertino, Joseph R, Vazquez, Alexei
الحاوية / القاعدة Cancer Metab (2015)

Functional annotation of rare gene aberration drivers of pancreatic cancer

بواسطة Tsang, Yiu Huen, Dogruluk, Turgut, Tedeschi, Philip M., Wardwell-Ozgo, Joanna, Lu, Hengyu, Espitia, Maribel, Nair, Nikitha, Minelli, Rosalba, Chong, Zechen, Chen, Fengju, Chang, Qing Edward, Dennison, Jennifer B., Dogruluk, Armel, Li, Min, Ying, Haoqiang, Bertino, Joseph R., Gingras, Marie-Claude, Ittmann, Michael, Kerrigan, John, Chen, Ken, Creighton, Chad J., Eterovic, Karina, Mills, Gordon B., Scott, Kenneth L.
الحاوية / القاعدة Nat Commun (2016)