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The metabolic demands of cancer cells are coupled to their size and protein synthesis rates

BACKGROUND: Although cells require nutrients to proliferate, most nutrient exchange rates of the NCI60 panel of cancer cell lines correlate poorly with their proliferation rate. Here, we provide evidence indicating that this inconsistency is rooted in the variability of cell size. RESULTS: We integr...

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Detalhes bibliográficos
Main Authors: Dolfi, Sonia C, Chan, Leo Li-Ying, Qiu, Jean, Tedeschi, Philip M, Bertino, Joseph R, Hirshfield, Kim M, Oltvai, Zoltán N, Vazquez, Alexei
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4178206/
https://ncbi.nlm.nih.gov/pubmed/24279929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2049-3002-1-20
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