The metabolic demands of cancer cells are coupled to their size and protein synthesis rates

BACKGROUND: Although cells require nutrients to proliferate, most nutrient exchange rates of the NCI60 panel of cancer cell lines correlate poorly with their proliferation rate. Here, we provide evidence indicating that this inconsistency is rooted in the variability of cell size. RESULTS: We integr...

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Библиографические подробности
Главные авторы: Dolfi, Sonia C, Chan, Leo Li-Ying, Qiu, Jean, Tedeschi, Philip M, Bertino, Joseph R, Hirshfield, Kim M, Oltvai, Zoltán N, Vazquez, Alexei
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2013
Предметы:
Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4178206/
https://ncbi.nlm.nih.gov/pubmed/24279929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2049-3002-1-20
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