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Molecular Crowding Defines a Common Origin for the Warburg Effect in Proliferating Cells and the Lactate Threshold in Muscle Physiology

Aerobic glycolysis is a seemingly wasteful mode of ATP production that is seen both in rapidly proliferating mammalian cells and highly active contracting muscles, but whether there is a common origin for its presence in these widely different systems is unknown. To study this issue, here we develop...

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Main Authors: Vazquez, Alexei, Oltvai, Zoltán N.
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2011
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3084886/
https://ncbi.nlm.nih.gov/pubmed/21559344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0019538
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