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Selective Killing of Tumors Deficient in Methylthioadenosine Phosphorylase: A Novel Strategy
BACKGROUND: The gene for methylthioadenosine phosphorylase (MTAP) lies on 9p21, close to the gene CDKN2A that encodes the tumor suppressor proteins p16 and p14ARF. MTAP and CDKN2A are homozygously co-deleted, with a frequency of 35 to 70%, in lung and pancreatic cancer, glioblastoma, osteosarcoma, s...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2009
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2684647/ https://ncbi.nlm.nih.gov/pubmed/19478948 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005735 |
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