Human Double-Negative Regulatory T-Cells Induce a Metabolic and Functional Switch in Effector T-Cells by Suppressing mTOR Activity

The recently discovered population of TCRαβ+ CD4–/CD8– (double-negative, DN) T-cells are highly potent suppressor cells in mice and humans. In preclinical transplantation models, adoptive transfer of DN T-cells specifically inhibits alloreactive T-cells and prevents transplant rejection or graft-vs....

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Haug, Tabea, Aigner, Michael, Peuser, Moritz M., Strobl, Carolin D., Hildner, Kai, Mougiakakos, Dimitrios, Bruns, Heiko, Mackensen, Andreas, Völkl, Simon
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6498403/
https://ncbi.nlm.nih.gov/pubmed/31105702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.00883
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados