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An Oscillatory Switch in mTOR Kinase Activity Sets Regulatory T Cell Responsiveness
There is a discrepancy between the in vitro anergic state of CD4(+)CD25(hi)FoxP3(+) regulatory T (Treg) cells and their in vivo proliferative capability. The underlying mechanism of this paradox is unknown. Here we show that the anergic state of Treg cells depends on the elevated activity of the mam...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3133602/ https://ncbi.nlm.nih.gov/pubmed/21145759 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2010.11.024 |
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