An Oscillatory Switch in mTOR Kinase Activity Sets Regulatory T Cell Responsiveness

There is a discrepancy between the in vitro anergic state of CD4(+)CD25(hi)FoxP3(+) regulatory T (Treg) cells and their in vivo proliferative capability. The underlying mechanism of this paradox is unknown. Here we show that the anergic state of Treg cells depends on the elevated activity of the mam...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Procaccini, Claudio, De Rosa, Veronica, Galgani, Mario, Abanni, Luisa, Calì, Gaetano, Porcellini, Antonio, Carbone, Fortunata, Fontana, Silvia, Horvath, Tamas L., La Cava, Antonio, Matarese, Giuseppe
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2010
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3133602/
https://ncbi.nlm.nih.gov/pubmed/21145759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2010.11.024
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