An Oscillatory Switch in mTOR Kinase Activity Sets Regulatory T Cell Responsiveness

There is a discrepancy between the in vitro anergic state of CD4(+)CD25(hi)FoxP3(+) regulatory T (Treg) cells and their in vivo proliferative capability. The underlying mechanism of this paradox is unknown. Here we show that the anergic state of Treg cells depends on the elevated activity of the mam...

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Bibliografiske detaljer
Main Authors: Procaccini, Claudio, De Rosa, Veronica, Galgani, Mario, Abanni, Luisa, Calì, Gaetano, Porcellini, Antonio, Carbone, Fortunata, Fontana, Silvia, Horvath, Tamas L., La Cava, Antonio, Matarese, Giuseppe
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3133602/
https://ncbi.nlm.nih.gov/pubmed/21145759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2010.11.024
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