An Oscillatory Switch in mTOR Kinase Activity Sets Regulatory T Cell Responsiveness

There is a discrepancy between the in vitro anergic state of CD4(+)CD25(hi)FoxP3(+) regulatory T (Treg) cells and their in vivo proliferative capability. The underlying mechanism of this paradox is unknown. Here we show that the anergic state of Treg cells depends on the elevated activity of the mam...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Procaccini, Claudio, De Rosa, Veronica, Galgani, Mario, Abanni, Luisa, Calì, Gaetano, Porcellini, Antonio, Carbone, Fortunata, Fontana, Silvia, Horvath, Tamas L., La Cava, Antonio, Matarese, Giuseppe
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3133602/
https://ncbi.nlm.nih.gov/pubmed/21145759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2010.11.024
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky