Pan-cancer Analysis of CDK12 Alterations Identifies a Subset of Prostate Cancers with Distinct Genomic and Clinical Characteristics

BACKGROUND: CDK12 genomic alterations occur in several tumor types, but little is known about their oncogenic role and clinical significance. OBJECTIVE: To describe the landscape of CDK12 alterations across solid cancers and the clinical features of CDK12-altered prostate cancer. DESIGN, SETTING, AN...

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Bibliografske podrobnosti
izdano v:Eur Urol
Main Authors: Nguyen, Bastien, Mota, Jose Mauricio, Nandakumar, Subhiksha, Stopsack, Konrad H., Weg, Emily, Rathkopf, Dana, Morris, Michael J., Scher, Howard I., Kantoff, Philip W., Gopalan, Anuradha, Zamarin, Dmitriy, Solit, David B., Schultz, Nikolaus, Abida, Wassim
Format: Artigo
Jezik:Inglês
Izdano: 2020
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7572747/
https://ncbi.nlm.nih.gov/pubmed/32317181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.eururo.2020.03.024
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