Platinum-Based Chemotherapy in Metastatic Prostate Cancer With DNA Repair Gene Alterations

PURPOSE: Alterations in DNA damage repair (DDR) genes occur in up to 25% of patients with metastatic castration-resistant prostate cancer (mCRPC) and may sensitize to platinum chemotherapy. We aimed to evaluate the efficacy of platinum-based chemotherapy in DDR-mutant (DDRmut) mCRPC. METHODS: We ass...

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Detalhes bibliográficos
Publicado no:JCO Precis Oncol
Main Authors: Mota, Jose Mauricio, Barnett, Ethan, Nauseef, Jones T., Nguyen, Bastien, Stopsack, Konrad H., Wibmer, Andreas, Flynn, Jessica R., Heller, Glenn, Danila, Daniel C., Rathkopf, Dana, Slovin, Susan, Kantoff, Philip W., Scher, Howard I., Morris, Michael J., Schultz, Nikolaus, Solit, David B., Abida, Wassim
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2020
Assuntos:
Original Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7446522/
https://ncbi.nlm.nih.gov/pubmed/32856010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/PO.19.00346
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