Platinum-Based Chemotherapy in Metastatic Prostate Cancer With DNA Repair Gene Alterations

PURPOSE: Alterations in DNA damage repair (DDR) genes occur in up to 25% of patients with metastatic castration-resistant prostate cancer (mCRPC) and may sensitize to platinum chemotherapy. We aimed to evaluate the efficacy of platinum-based chemotherapy in DDR-mutant (DDRmut) mCRPC. METHODS: We ass...

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Bibliografske podrobnosti
izdano v:JCO Precis Oncol
Main Authors: Mota, Jose Mauricio, Barnett, Ethan, Nauseef, Jones T., Nguyen, Bastien, Stopsack, Konrad H., Wibmer, Andreas, Flynn, Jessica R., Heller, Glenn, Danila, Daniel C., Rathkopf, Dana, Slovin, Susan, Kantoff, Philip W., Scher, Howard I., Morris, Michael J., Schultz, Nikolaus, Solit, David B., Abida, Wassim
Format: Artigo
Jezik:Inglês
Izdano: American Society of Clinical Oncology 2020
Teme:
Original Reports
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7446522/
https://ncbi.nlm.nih.gov/pubmed/32856010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/PO.19.00346
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